GRET Physiopathologie

GRET Pathophysiology

The teams that make up the "Pathophysiology" GRET study the mechanisms of interaction of cells with each other and with their environment in different physiological contexts (tissue homeostasis, differentiation, immunity) or pathological contexts (infectious diseases, metabolic or inflammatory diseases, neurodegenerative diseases, cancer). We are interested in these questions from the perspective of their genetic control and we study the signaling pathways and effector mechanisms involved in cellular responses with the prospect of contributing to the identification of new targets and therapeutic approaches.

Coordinator: Sophie Thenet

 

Main areas of research

  • Epithelial and endothelial barriers and gut microbiota

We are interested in the impact of different classes of metabolites from the gut microbiota on the function of the intestinal and endothelial vascular barrier in the context of diseases with an inflammatory component, with a particular interest in chronic inflammatory bowel diseases. 
Sylvie Demignot, Diego Garcia-Weber, Sophie Thenet

  • Cell differentiation

Our group studies how energy metabolism determines cell differentiation. 
Andràs Paldi

  • Hematopoietic cells

We are interested in understanding hematopoietic differentiation under normal and pathological conditions with a particular interest in the role of environmental contaminants, such as dioxins, in the pathological processes of induction of acute myeloid leukemias. Imaging techniques involving bioinformatics and Artificial Intelligence technologies are also developed for qualitative and quantitative analyses of hematopoietic cells. 
Thi-My-Anh Neildez, Daniel Stockholm

  • Arbovirology

We study the interactions between arboviruses (i.e. viruses transmitted to humans and/or animals by blood-sucking arthropods) and their mammalian hosts/insect vectors. Our main objective is to better understand, anticipate and control the threat posed by these viruses, in particular by identifying the key (a)biotic determinants of their pathogenicity or vectorial capacity. 
Frédérick Arnaud, Vincent Raquin, Maxime Ratinier, Barbara Viginier

  • Bioelectromagnetism

We are interested in bioelectromagnetism, i.e. the interdisciplinary field at the interface between biology, medicine, physics, and electromagnetism. In particular, we assess the potential health risks associated with human exposure to environmental electromagnetic fields and set up experiments to determine the potential of ultrashort electrical pulses (nsPEFs) for biomedical applications. 
Isabelle Lagroye, Rosa Orlacchio

  • Tissue Engineering

We develop biomimetic and functional materials in order to establish controlled and modular micro-environments for applications in cell or gene therapy, for the controlled release of active ingredients or for the understanding of pathophysiological mechanisms. 
Emmanuel Belamie, Marie-Noëlle Labour, Jade Berthelot

  • Mycology

We study adaptations of the transcriptome of Cryptococcus neoformans, an opportunistic fungal pathogen classified as critical by the WHO, in the context of infection. This study aims to understand the mechanisms underlying the pathogenicity of this yeast : how it adapts to the human host, evades the immune system or resists antifungal treatments. 
Jessie Colin

 

List of ECs/research units and associated websites

S. Demignot, D. Garcia-Weber, S. Thenet      
UMRS 938 - Saint-Antoine Research Center, Microbiota, Gut and Inflammation     team
Saint-Antoine Hospital - 27, rue de Chaligny - 75012 Paris      
https://www.crsa.fr/equipe-philippe-seksik.html

T.-M.-A. Neildez, A. Paldi, D. Stockholm     
UMRS 938 - Saint-Antoine Research Center, Hematopoietic and Leukemia Development: Diseases and Cell     Therapy team
Saint-Antoine Hospital - 27, rue de Chaligny - 75012 Paris       
https://www.crsa.fr/equipe-francois-delhommeau.html

F. Arnaud, V. Raquin, M. Ratinier, B. Viginier     
UMR 754 - IVPC, Bunyaviral    Biology team
Université Lyon 1 - Bâtiment Recherche - Étage 3 - 50, avenue Tony Garnier - 69007 Lyon     
https://www6.lyon-grenoble.inrae.fr/ivpc/Equipes-de-recherche/BUNYA

I. Lagroye, R. Orlacchio    
UMR 5218 - SANE Team (Health & Environment), bioelectronics   group
351, Cours de la libération - 33405 Talence cedex    
https://www.ims-bordeaux.fr/fr/recherche/groupes-recherche/35-bioelectronique/sane/18-sane

E. Belamie, M.-N. Labour, J. Berthelot   
UMR 5253 - Institut Charles Gerhardt Montpellier (ICGM) - Department of Chemistry & MacroMolecular   Materials
Pôle Chimie Balard Recherche - 1919, route de Mende - 34293 Montpellier cedex 5   
https://www.icgm.fr/linstitut/les-departements/d2/

J. Colin  
Unit "RNA Biology of Fungal Pathogens" - Department of Mycology 
Institut Pasteur - 25-28, rue du Docteur Roux - 75015, Paris  
https://research.pasteur.fr/fr/team/rna-biology-of-fungal-pathogens/